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Sequential Pathology after Experimental Infection with MarineViral Hemorrhagic Septicemia Virus Isolates of Low and HighVirulence in Turbot (Scophthalmus maximus L.)

Three marine viral hemorrhagic septicemia virus isolates were used   to bath challenge turbot with the purpose of studying mortality and   the pathology and antigen distribution over time. Two high-virulence  isolates, 86 /94, 4p168 and a low-virulence isolate 1p3 from a   Baltic Sea herring were used. Organ samples were collected   sequentially at 2, 4, 7, 1 , 15, 2 , 25, and 45 days postinfection.   Specimens were processed for virology, histopathology, and   immunohistochemistry. Organs during the early stages of infection   (from 2 to 7 days) had virus isolation from all three groups only on   day 7. Virus titer in kidney and heart sampled at day 25 was higher   for the two virulent isolates compared with the low-virulence   isolate. The viral distribution in situ of the two more virulent   isolates from turbot (86 /94) and herring (4p168) resembled viral   hemorrhagic septicemia in rainbow trout with regard to the target   organs. Early infection of endothelial cells in both kidney and   heart was observed. Accumulated mean mortality was 41.5% for the   turbot isolate 86 /94, 48% for the herring isolate 4p168, and 3.5%   for the herring isolate 1p3.     This study revealed that the isolates from turbot (86 /94) and   herring (4p168) induced significantly higher mortality compared with   the virus-free control and the herring isolate (1p3). The onset of   mortality is markedly later in turbot compared with what is seen in  rainbow trout.    (VHS); (VHSv); (viral hemorrhagic septicemia); (viral haemorrhagic   septicaemia); (viral hemmorrhagic septicemia)

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Start Date
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Oystein EvensenPrincipal Investigator
Associated with 4 projects
Bjorn BrudesethResearcher
Associated with 3 projects
The European Commission $ 0.00CADEstimates

Funding 2 projects for a total of $0.00

Funding 2 projects for a total of $0.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Impact of Pollutants
Exotic Species
Resource Management
Resource Being Monitored
Beneficial Use Impairment Assessments
Fish Tumours or Other Deformities
Loss of Fish and Wildlife Habitat
Tainting of Fish and Wildlife Populations
Biology And Life History
Parasites and Diseases
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats
  • Annex Numbers
    Annex Numbers
    Research & Development
  • Annex 17
    Annex 17
    Impact of water quality and AIS on fish and wildlife populations and habitats

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