Skip to main content

Studies on Pathogenesis Following Single and Double Infection with Viral Hemorrhagic Septicemia Virus and Infectious Hematopoietic Necrosis Virus in Rainbow Trout (Oncorhynchus mykiss)

Rainbow trout (Oncorhynchus mykiss) were bath challenged with viral   hemorrhagic septicemia (VHS) virus or infectious hematopoietic   necrosis (IHN) virus or with both viruses simultaneously. The viral   distribution and development of histologic lesions were examined   using immunohistochemistry, while virus titer in kidney was   determined by viral titration in cell culture. Single infections   with VHS virus and IHN virus showed similar distributions of virus   in internal organs. The early identification of virus in gill   epithelium, 1 and 2 days postinfection (PI) for VHS virus and IHN   virus, respectively, indicates that this organ is the point of entry   for both viruses. The detection of VHS virus at 1 day PI and 3 days   PI for IHN virus is indicative of kidney and spleen being the target   organs for these viruses. A simultaneous infection of VHS virus and   IHN virus resulted in both viruses establishing an infection.   Further double infection did not result in a statistically   significant lower titer of both viruses in kidney but a more   restricted distribution of IHN virus in internal organs compared   with the single infected group. The most striking finding is that,   for IHN virus, virus was not detected in the brain in situ in the   double-infected group. This study provides support for the   conclusion that simultaneous infection with two piscine   rhabdoviruses in a susceptible host results in some degree of   interaction at the cell level, leading to a reduced systemic   distribution of IHN virus.    (VHS); (VHSv); (viral hemorrhagic septicemia); (viral haemorrhagic   septicaemia); (viral hemmorrhagic septicemia)

In progress
Start Date
End Date
Bjorn BrudesethPrincipal Investigator
Associated with 3 projects
Oystein EvensenPrincipal Investigator
Associated with 4 projects
The European Commission $ 0.00CADEstimates

Funding 2 projects for a total of $0.00

Funding 2 projects for a total of $0.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Impact of Pollutants
Exotic Species
Resource Management
Resource Being Monitored
Beneficial Use Impairment Assessments
Fish Tumours or Other Deformities
Loss of Fish and Wildlife Habitat
Tainting of Fish and Wildlife Populations
Biology And Life History
Parasites and Diseases
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats
  • Annex Numbers
    Annex Numbers
    Research & Development
  • Annex 17
    Annex 17
    Impact of water quality and AIS on fish and wildlife populations and habitats

The Great Lakes - St. Lawrence Research Inventory is an
interactive, Internet-based, searchable database created as a tool to collect and disseminate
up-to-date information about research projects in the
Great Lakes - St. Lawrence Region.