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An In Vitro Strategy for Understanding the Neural MechanismsUnderlying Pheromone-Activated Movements in the Sea Lamprey

The successful spawning of sea lampreys depends on reproductive phase  lampreys moving to   pheromone sources. We hypothesize that this movement in response  odorous cues ensues   through a specific neural pathway linking pheromone sensory input to  locomotion. We will   delineate this pathway from sensory input to motor output, through  neuro-anatomical tract   tracing, electrophysiology and live-cell imaging. An understanding of  the relationship   between pheromone sensation and locomotion is directly relevant to the  goal of the sea   lamprey control program in the Great Lakes.  This knowledge will  provide functional   endpoints useful for developing and applying pheromonal strategies,  and will complement   ongoing investigation of gene expression during maturation.  While  recording extracellular   field potentials from the peripheral olfactory organ by the  electro-olfactogram (EOG) lets us   know if the pheromone is an odor, it fails to monitor central  responses that regulate   locomotion.  The "in vitro" approach of examining lamprey neurobiology  has led to   discoveries of neural control of vertebrate locomotion.  We will  expand the use of this   method for investigating pheromone-activated locomotion, with the goal  of assisting with   lamprey population management. 

Status
In progress
Type
Project
Start Date
End Date
Researchers
Rejean DubucPrincipal Investigator
Associated with 2 projects
Agencies
Great Lakes Fishery Commission $ 106,995.00CADActual

Funding 54 projects for a total of $5,089,137.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Cellular
Organism
Impact of Pollutants
Exotic Species
Resource Management
Fisheries
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats

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Great Lakes - St. Lawrence Region.