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Interpreting the biological significance of bioaccumulation data: A field test of the critical body residue hypothesis

Our work with Hyallela has shown that once a critical body residue for chronic effects has been achieved, the effect associated with that tissue concentration will be shown even if the organism is removed to clean media and the tissue residues fall into an innocuous range. This can confound interpretation of results if organisms are moving from contaminated to uncontaminated areas in the field. The stability of effects, throughout the response spectrum, must be studied in order in order to provide interpretive information. The working hypothesis is that the biological response associated with a particular effect will be realized once the relevant tissue level is reached. Time-course studies in which organisms are held at a toxic body burden for varying lengths of time, followed by recovery periods of various lengths in clean media will be performed to establish the stability of the tissue concentration-effect relationship.  

Status
In progress
Type
Project
Start Date
End Date
Scope of Study
Field Investigation
Scale of Phenomena
Organism
State Province
Ohio
Annex Numbers
Surveillance and Monitoring

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