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Expression of inducible CC chemokines in rainbow trout (Oncorhynchus mykiss) in response to a viral haemorrhagic septicemia virus (VHSV) DNA vaccine and interleukin 8

In rainbow trout (Oncorhynchus mykiss), at least three CXC   chemokines and eighteen CC chemokine sequences have been discovered   in the past years, although no studies concerning their bioactivity   have been performed yet. We have studied the expression of five   different CC chemokines that cluster into the group of inducible   chemokines (CK5A, CK5B, CK6, CK7A and CK7B) in trout injected with a   plasmid coding for the glycoprotein G gene (pMCV1.4-G) of viral  haemorrhagic septicemia virus (VHSV). In a previous work, we had   demonstrated that a plasmid coding for the CXC chemokine interleukin   8 (IL-8, pIL8+) when co-administered with pMCV1.4-G was able to   modulate the expression of induced pro-inflammatory cytokines,   therefore, we have also studied the expression of these inducible CC   chemokines in fish injected with pMCV1.4-G in the presence of pIL8+,   study that will also help establish the relations among the  different chemokine groups. All chemokines were induced in the head   kidney of fish injected with the DNA vaccine, and the co-  administration of pIL8+ together with the vaccine modulated the   expression of all CC chemokines studied. In this sense, expression   of the inducible CC chemokines was also studied in trout head kidney   leucocytes treated with supernatants from EPC cells transfected with   pIL8+. In this case, all CC chemokines studied except for CK5B were  significantly induced by rainbow trout IL-8.    (VHS); (VHSv); (viral hemorrhagic septicemia); (viral haemorrhagic   septicaemia); (viral hemmorrhagic septicemia)

Status
In progress
Type
Project
Start Date
End Date
Researchers
Carolina TafallaPrincipal Investigator
Associated with 1 projects
Esther SanchezResearcher
Associated with 1 projects
Agencies

Funding 1 projects for a total of $0.00

Funding 1 projects for a total of $0.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Cellular
Organism
Impact of Pollutants
Exotic Species
Resource Management
Fisheries
Resource Being Monitored
Fisheries
Beneficial Use Impairment Assessments
Fish Tumours or Other Deformities
Loss of Fish and Wildlife Habitat
Tainting of Fish and Wildlife Populations
Biology And Life History
Parasites and Diseases
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats
General
Monitoring
Annex
  • Annex Numbers
    Annex Numbers
    Research & Development
  • Annex 17
    Annex 17
    Impact of water quality and AIS on fish and wildlife populations and habitats

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