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Parallel Toxicogenomic Resources for Zebrafish and Rainbow Trout:Identifying Conserved Molecular Biomarkers of Toxicant Exposure

This new project will use genomic tools to identify toxicant-  response molecular biomarkers in zebrafish and rainbow trout for use   in assays evaluating the potential effects of exposure to   persistant, bioaccumulative toxicants on fish. The investigators   will combine DNA microarray work with quantitative reverse   transcription-polymerase chain reaction methodologies to identify   embryonic and larval genes responsive to dioxin (TCDD),  polychlorinated biphenyls (PCBs) and methylmercury (MeHg) exposure.   They plan to sequence about 2 ,    toxicant-response transcripts for   zebrafish and rainbow trout and create publicly accessible,   functionally annotated, expressed sequence tag databases - a   biomarker library that can be used as reference for examining   toxicant responses among Great Lakes wild fish species.    (human health); (fish consumption advisories); (fish consumption   advisory); (fish consumption); (chemicals of concern); (chemical of   concern); (toxic organics); (toxic organic); (PCB's); (PCBs); (PCB);   (polychlorinated biphenyl); (polychlorinated biphenyl);   (methylmercury); (MeHg); (POP's); (POPs); (POP); (persistent organic   pollutant); (persistent organic pollutants); (TCDD's); (TCDD);   (dioxins); (dioxin); (polychlorinated dibenzodioxins); (PCDD's);   (PCDD); (2,3,7,8-tetrachlorodibenzo-p-dioxin); (rainbow trout);   (zebrafish); (Oncorhynchus mykiss); (Danio rerio)

Status
In progress
Type
Project
Start Date
End Date
Scope of Study
Laboratory Investigation
Scale of Phenomena
Biochemical
Organism
Physical/Chemical
Impact of Pollutants
Toxic Metals
Resource Management
Fisheries
Annex Numbers
Persistent Toxic Substances
Specific Objectives for toxic substances and effluents

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up-to-date information about research projects in the
Great Lakes - St. Lawrence Region.