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Toxicity and Estrogenic Activity of Polybrominated Diphenyl Ethers (PBDEs)

Polybrominated biphenyl ethers (PBDEs) are widely used flame   retardants whose concentrations are rapidly increasing in the   environment, including the Great Lakes.     This research will:  1) Determine estrogenic activity of BDE-47 and BDE-99 using the E-  screen assay, which uses MCF-7 breast cancer cells  2) Determine the acute and chronic toxicity of BDE-47 to the aquatic   invertebrate, Ceriodaphnia dubia. NOAEL and LOAEL values and an   acute to chronic ratio will be determined if possible.  3) Measure the concentration of PBDEs in sediments of the Sheboygan   River Area of Concern  4) Measure the concentration of PBDEs in wastewater treatment plant   and industrial effluents in the Sheboygan River AOC.    The toxicological portion of the project will provide data that will   be helpful in determining possible future Great Lakes water quality   criteria for PBDEs. Because concentrations of PBDEs in sediment have   been shown to increase downstream of some industries and are high in   sewage sludge, the Sheboygan River basin, with its history of   plastics and furniture manufacturing, represents an ideal location   to examine possible industrial and municipal sources of PBDEs to   Lake Michigan.    (AOC); (area of concern); (Sheboygan River); (PBDE); (PBDE's);   (PBDEs); (polybrominated biphenyl ethers); (polybrominated biphenyl   ether); (toxic organics); (toxic organic); (POP); (POPs); (POP's);   (persistent organic pollutants); (persistent organic pollutant);   (flame retardant); (flame retardants); (Wisconsin)

Status
In progress
Type
Project
Start Date
End Date
Scope of Study
Field Investigation
Laboratory Investigation
Scale of Phenomena
Biochemical
Physical/Chemical
Impact of Pollutants
Toxic Organics
Lake Basin Connecting Channels
Lake Michigan
State Province
Wisconsin
Resource Being Monitored
Wildlife
Beneficial Use Impairment Assessments
Bird or Animal Deformities or Reproduction Problems
Loss of Fish and Wildlife Habitat
Tainting of Fish and Wildlife Populations
Annex Numbers
Persistent Toxic Substances
Remedial Action Plans and Lakewide Management Plans
Research & Development
Specific Objectives for toxic substances and effluents
Annex 17
Ecotoxicity and toxicity effects of pollutants related to developing Annex 1 specific objectives
General
Monitoring
Annex
  • Annex Numbers
    Annex Numbers
    Persistent Toxic Substances
    Remedial Action Plans and Lakewide Management Plans
    Research & Development
    Specific Objectives for toxic substances and effluents
  • Annex 17
    Annex 17
    Ecotoxicity and toxicity effects of pollutants related to developing Annex 1 specific objectives

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Great Lakes - St. Lawrence Region.