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A molecular microbiological search for active biphenyl dioxygenases in polychlorinated biphenyl-contaminated sediments

Polychlorinated biphenyls (PCBs) are toxic, carcinogenic, and   bioaccumulative compounds that are often found in lake and river   soils and sediments. PCBs in soils and sediments represent a human   health risk, especially if natural processes promote PCB   volatilization and subsequent exposure to humans. Biodegradation of   PCBs would reduce the risk of adverse human health effects, but this   process is poorly understood in sediments. The objective of this   research is to test the hypothesis that aerobic, PCB-degrading   bacteria are present and active in PCB-contaminated sediments from   Indiana Harbor. Preliminary studies revealed aerobic PCB   biodegradation potential, but additional experiments are needed to   determine if PCB-degraders are active in these sediments. An array   of experimental approaches, some of which are innovative, involving   reverse-transcription (RT)-PCR, real-time RT-PCR, proteomics, and   metabolite analysis are proposed.    (PCB); (PCB's); (PCBs); (polychlorinated biphenyls);   (polychlorinated biphenyl); (chemical of concern); (chemicals of   concern); (aerobic bacteria); (bacteria); (Indiana); (persistent   organics); (persistent organic pollutants); (persistent organic   pollutant); (POP's); (POP); (POPs); (toxic organic); (toxic   organics); (biphenyl dioxygenases); (biphenyl dioxygenase); (Lake   Michigan)

Status
In progress
Type
Project
Start Date
End Date
Scope of Study
Field Investigation
Laboratory Investigation
Scale of Phenomena
Biochemical
Physical/Chemical
Impact of Pollutants
Toxic Organics
Lake Basin Connecting Channels
Lake Michigan
State Province
Indiana
Resource Being Monitored
Bottom Sediment
Human Health
Suspended Sediments
Program Drivers
Lakewide Management Plans (LaMP)
Beneficial Use Impairment Assessments
Fish Tumours or Other Deformities
Loss of Fish and Wildlife Habitat
Restrictions of Fish and Wildlife Consumption
Tainting of Fish and Wildlife Populations
Annex Numbers
Contaminated Sediment
Research & Development
Specific Objectives for toxic substances and effluents
Annex 17
Mass transfer of pollutants between GL Basin Ecosystem components
Relationship of contaminated sediments on ecosystem health
General
Monitoring
Annex
  • Annex Numbers
    Annex Numbers
    Contaminated Sediment
    Research & Development
    Specific Objectives for toxic substances and effluents
  • Annex 17
    Annex 17
    Mass transfer of pollutants between GL Basin Ecosystem components
    Relationship of contaminated sediments on ecosystem health

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up-to-date information about research projects in the
Great Lakes - St. Lawrence Region.