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DEVELOPMENT OF A CONTROLLED-RELEASE POLYMER FOR DEPLOYMENT OF THE SEA LAMPREY PHEROMONE 3-KETO-PETROMYZONOL SULFATE

A substantial technological barrier to the implementation of a   pheromone-based control program for sea lamprey is the development of   a reliable and cost-effective means to deploy synthesized pheromones   into a receiving water body that meets the legal requirements of   FIFRA. Biological research has employed peristaltic pumps that   mechanically meter pheromone/solvent mixtures into streams.  Such a   method will prove costly and difficult to manage when contemplating   simultaneous pheromone releases into hundreds of water bodies as a   control activity. To date, no effort has been undertaken to identify   or construct an appropriate sea lamprey pheromone emitter. Polymers   are widely used for the controlled release of many agents ?   pharmaceuticals, fertilizers, perfumes, and many more. Here, we   propose to prepare, evaluate, and test a polymer-based release agent   for the deployment 3-keto-Petromyzonol Sulfate and similar bile-acid   pheromone components being developed for use in sea lamprey   management.      Our approach will encompass four steps. First, we will perform   preliminary experiments with various candidate resins.  Release from   the resins will be monitored by instrumental methods. Conditions for   release (temperature ~1  °C, pH ~7.5) will be modeled on water   conditions in the streams where use is proposed. We will select up to   four resins as the best candidates. Second, we will bind tracer dyes   to the resin and determine its release rate under laboratory   conditions to confirm it is released in a fashion similar to 3kPZS.   Third, we will perform a field test of the candidate resin(s) with   the tracer dye in summer 2 1  to ascertain performance (release rate,   duration, etc.). The results will be used to further optimize the   resin-3kPZS composition, and may allow us to select a single resin as   the best vehicle for controlled release. Finally, we will compare   ovulating female sea lamprey response to 3kPZS emitted via the polymer  (s) vs. a pumped mixture of 3kPZS eluted in methanol and water in a   natural stream. The purpose of this comparison is to ascertain   whether any feature of the polymer emitter disrupts the long-distance   attraction response and thereby compromises the efficacy of the   pheromone component. 

Status
In progress
Type
Project
Start Date
End Date
Researchers
Michael WagnerResearcher
Associated with 6 projects
James HansonPrincipal Investigator
Associated with 1 projects
Agencies
Great Lakes Fisheries Commission $ 126,750.00USDEstimates

Funding 2 projects for a total of $136,750.00
Scope of Study
Field Investigation
Laboratory Investigation
Scale of Phenomena
Biochemical
Organism
Physical/Chemical
Resource Management
Fisheries
Frequency
Annual
Region Being Monitored
Tributary Mouth
Biology And Life History
Physiology and Behavior
Control And Mitigation
Chemical Measures
Ecosystem Effects
Habitat (physical / chemical)
Prevention and Introduction
Determination of Preventive
Spread of Established ANS Populations
Natural Barriers
Socio-economic Consideration and Analysis
Resource Management Issues
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats
General
Aquatic Nuisance Species
Annex
  • Annex Numbers
    Annex Numbers
    Research & Development
  • Annex 17
    Annex 17
    Impact of water quality and AIS on fish and wildlife populations and habitats

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