Skip to main content
hyi
Banner
banner
bn

Genomic Approach to Understanding TCDD Toxicity in Zebrafish

This project will address gene expression changes in zebrafish   associated with TCDD exposures. Besides being nearly transparent,   the zebrafish is the first fish to have had its genome mapped, which   makes it ideal for research on the genetic effects of exposure to   toxic contaminants. The goal of the project is to determine whether   different TCDD responses in tissues correspond to a distinct gene   expression pattern. Using DNA microarrays, the investigators hope to   determine whether gene expression patterns can be used to predict   sublethal toxicity; if successful, the microarray approach may be   used as a screening tool to predict responses in wild fishes. This   work directly addresses the strategic priority of developing gene   microarrays in fish for identifying alterations in gene expression   associated with chemical and physical stresses.     (polychlorinated dibenzodioxins); (polychlorinated dibenzodioxin);   (TCDD); (TCDD's); (TCDDs); (zebrafish); (dioxin); (dioxins);   (organochloride); (organochlorides); (POP's); (POPs); (POP);   (persistent organic pollutant); (persistent organic pollutants);   (chemical of concern); (chemicals of concern); (toxic organic);   (toxic organics)

Status
In progress
Type
Project
Start Date
End Date
Researchers
Warren HeidemanPrincipal Investigator
Associated with 1 projects
Lingjun LiResearcher
Associated with 1 projects
Richard PetersonResearcher
Associated with 1 projects
Agencies
Wisconsin Sea Grant $ 382,807.00USDEstimates

Funding 3 projects for a total of $395,352.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Organism
Physical/Chemical
Impact of Pollutants
Toxic Organics
Resource Management
Fisheries
Annex Numbers
Persistent Toxic Substances
Research & Development
Specific Objectives for toxic substances and effluents
Annex 17
Ecotoxicity and toxicity effects of pollutants related to developing Annex 1 specific objectives
General
Annex
  • Annex Numbers
    Annex Numbers
    Persistent Toxic Substances
    Research & Development
    Specific Objectives for toxic substances and effluents
  • Annex 17
    Annex 17
    Ecotoxicity and toxicity effects of pollutants related to developing Annex 1 specific objectives

The Great Lakes - St. Lawrence Research Inventory is an
interactive, Internet-based, searchable database created as a tool to collect and disseminate
up-to-date information about research projects in the
Great Lakes - St. Lawrence Region.