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DEVELOPING A LAMPREY CONTRACEPTIVE

There is a need for additional methods to control sea lamprey in the Great Lakes. Chemicals that inhibit lamprey estrogen receptor [ER] can be used as contraceptives to control female lamprey reproduction. We recently constructed a 3D model of lamprey ER. Our 3D model predicts that lamprey ER contains a unique structure containing Met-4 9 and adjacent amino acids that bind the D ring of estrogens. The key hypothesis is that due to this unique structure, there are chemicals that can selectively inhibit estrogen activation of lamprey ER and not be toxic to other animals. We have preliminary in silico data that identifies eight potential compounds based on using our 3D model of lamprey ER as a template for virtual screening of chemical library in the NCI Diversity Set with Autodock 4. These chemicals have a lower affinity for human ERalpha and ERbeta. Based on this preliminary data, we hypothesize that one or more of these eight chemicals will selectively inhibit lamprey ER and not be toxic to zebrafish embryos. We will test this hypothesis by investigating the chemicals for inhibition of estrogen-activated transcription by lamprey ER and by exposing zebrafish embryos to these chemicals. We also hypothesize that we can use in silico analysis to find additional chemicals from a natural products database that are specific for lamprey ER and have little or no toxicity for animals. A contraceptive for female lamprey can be used with male pheromones and trapping to control sea lamprey.

Status
In progress
Type
Project
Start Date
End Date
Agencies
Great Lakes Fishery Commission $ 55,388.00USDEstimates

Funding 54 projects for a total of $5,089,137.00
Scope of Study
Laboratory Investigation
Scale of Phenomena
Biochemical
Cellular
Physical/Chemical
Processes
Treatment / Manufacturing Processes
State Province
Michigan
Ontario
Biology And Life History
Physiology and Behavior
Control And Mitigation
Chemical Measures
Spread of Established ANS Populations
Rate of Spread
Annex Numbers
Research & Development
Annex 17
Impact of water quality and AIS on fish and wildlife populations and habitats
General
Aquatic Nuisance Species
Annex
  • Annex Numbers
    Annex Numbers
    Research & Development
  • Annex 17
    Annex 17
    Impact of water quality and AIS on fish and wildlife populations and habitats

The Great Lakes - St. Lawrence Research Inventory is an
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up-to-date information about research projects in the
Great Lakes - St. Lawrence Region.